10% Niacinamide Serum

Key compounds: Niacinamide, Other ingredients

How to take: Apply to clean, dry skin once or twice daily, typically after cleansing and toning, before heavier moisturizers or oils.

Absorption: Niacinamide, a water-soluble form of Vitamin B3, is readily absorbed topically by the stratum corneum due to its small molecular weight and amphiphilic properties, allowing it to penetrate the skin barrier effectively. Its absorption is not dependent on dietary intake of food, fat, or water.

Stacks well with: Niacinamide pairs excellently with retinoids to mitigate potential irritation and enhance skin barrier function, and with hyaluronic acid for superior hydration and overall skin health.

Evidence tier: moderate